Cyclophilin A Levels Dictate Infection Efficiency of Human Immunodeficiency Virus Type 1 Capsid Escape Mutants A92E and G94D

Cyclophilin A (CypA) is an important human immunodeficiency virus type 1 (HIV-1) cofactor in human cells. HIV-1 A92E and G94D capsid escape mutants arise during CypA inhibition and in certain cell lines are dependent on CypA inhibition. Here we show that dependence on CypA inhibition is due to high...

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Bibliographic Details
Main Authors: Ylinen, Laura M. J., Schaller, Torsten, Price, Amanda, Fletcher, Adam J., Noursadeghi, Mahdad, James, Leo C., Towers, Greg J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643744/
https://ncbi.nlm.nih.gov/pubmed/19073742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01876-08
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