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Fusion of Cyclophilin A to Fv1 Enables Cyclosporine-Sensitive Restriction of Human and Feline Immunodeficiency Viruses
TRIM5α is a potent intracellular antiviral restriction factor governing species-specific retroviral replication. In the New World species owl monkey the coding region for the viral binding B30.2 domain of TRIM5α has been replaced by a cyclophilin A (CypA) pseudogene by retrotransposition. The result...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2045386/ https://ncbi.nlm.nih.gov/pubmed/17609268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00616-07 |
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