Cyclophilin A Renders Human Immunodeficiency Virus Type 1 Sensitive to Old World Monkey but Not Human TRIM5α Antiviral Activity

TRIM5α is an important mediator of antiretroviral innate immunity influencing species-specific retroviral replication. Here we investigate the role of the peptidyl prolyl isomerase enzyme cyclophilin A in TRIM5α antiviral activity. Cyclophilin A is recruited into nascent human immunodeficiency virus...

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Bibliographic Details
Main Authors: Keckesova, Zuzana, Ylinen, Laura M. J., Towers, Greg J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472055/
https://ncbi.nlm.nih.gov/pubmed/16641261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.10.4683-4690.2006
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