Potent Lentiviral Restriction by a Synthetic Feline TRIM5 Cyclophilin A Fusion

A synthetic feline TRIM5-cyclophilin A fusion protein (feTRIMCyp) was generated and transduced into feline cells. feTRIMCyp was highly efficient at preventing infection with human (HIV) and feline (FIV) immunodeficiency virus pseudotypes, and feTRIMCyp-expressing cells resisted productive infection...

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Detalhes bibliográficos
Main Authors: Dietrich, Isabelle, Macintyre, Angela, McMonagle, Elizabeth, Price, Amanda J., James, Leo C., McEwan, William A., Hosie, Margaret J., Willett, Brian J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919025/
https://ncbi.nlm.nih.gov/pubmed/20554781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00858-10
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