EDEM1 targets misfolded HLA-B27 dimers for endoplasmic reticulum associated degradation

OBJECTIVE: HLA-B27 forms misfolded heavy chain dimers, which may predispose individuals to inflammatory arthritis by inducing endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). We wanted to define the role of the UPR induced ER associated degradation (ERAD) pathway in the dis...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Guiliano, David B., Fussell, Helen, Lenart, Izabela, Tsao, Edward, Nesbeth, Darren, Fletcher, Adam J., Campbell, Elaine C., Yousaf, Nasim, Williams, Sarah, Santos, Susana, Cameron, Amy, Towers, Greg J., Kellam, Paul, Hebert, Daniel N., Gould, Keith, Powis, Simon J., Antoniou, Antony N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399817/
https://ncbi.nlm.nih.gov/pubmed/25132672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38809
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