EDEM1 targets misfolded HLA-B27 dimers for endoplasmic reticulum associated degradation

OBJECTIVE: HLA-B27 forms misfolded heavy chain dimers, which may predispose individuals to inflammatory arthritis by inducing endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). We wanted to define the role of the UPR induced ER associated degradation (ERAD) pathway in the dis...

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Bibliographic Details
Published in:Arthritis Rheumatol
Main Authors: Guiliano, David B., Fussell, Helen, Lenart, Izabela, Tsao, Edward, Nesbeth, Darren, Fletcher, Adam J., Campbell, Elaine C., Yousaf, Nasim, Williams, Sarah, Santos, Susana, Cameron, Amy, Towers, Greg J., Kellam, Paul, Hebert, Daniel N., Gould, Keith, Powis, Simon J., Antoniou, Antony N.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399817/
https://ncbi.nlm.nih.gov/pubmed/25132672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38809
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