EDEM1 targets misfolded HLA-B27 dimers for endoplasmic reticulum associated degradation

OBJECTIVE: HLA-B27 forms misfolded heavy chain dimers, which may predispose individuals to inflammatory arthritis by inducing endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). We wanted to define the role of the UPR induced ER associated degradation (ERAD) pathway in the dis...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Arthritis Rheumatol
Glavni autori: Guiliano, David B., Fussell, Helen, Lenart, Izabela, Tsao, Edward, Nesbeth, Darren, Fletcher, Adam J., Campbell, Elaine C., Yousaf, Nasim, Williams, Sarah, Santos, Susana, Cameron, Amy, Towers, Greg J., Kellam, Paul, Hebert, Daniel N., Gould, Keith, Powis, Simon J., Antoniou, Antony N.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399817/
https://ncbi.nlm.nih.gov/pubmed/25132672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38809
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items