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TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription
TRIM5α is an antiviral, cytoplasmic, E3 ubiquitin (Ub) ligase that assembles on incoming retroviral capsids and induces their premature dissociation. It inhibits reverse transcription of the viral genome and can also synthesize unanchored polyubiquitin (polyUb) chains to stimulate innate immune resp...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4551353/ https://ncbi.nlm.nih.gov/pubmed/26101372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490361 |
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