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TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription
TRIM5α is an antiviral, cytoplasmic, E3 ubiquitin (Ub) ligase that assembles on incoming retroviral capsids and induces their premature dissociation. It inhibits reverse transcription of the viral genome and can also synthesize unanchored polyubiquitin (polyUb) chains to stimulate innate immune resp...
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| Publicado en: | EMBO J |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4551353/ https://ncbi.nlm.nih.gov/pubmed/26101372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490361 |
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