TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription

TRIM5α is an antiviral, cytoplasmic, E3 ubiquitin (Ub) ligase that assembles on incoming retroviral capsids and induces their premature dissociation. It inhibits reverse transcription of the viral genome and can also synthesize unanchored polyubiquitin (polyUb) chains to stimulate innate immune resp...

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Bibliografske podrobnosti
izdano v:EMBO J
Main Authors: Fletcher, Adam J, Christensen, Devin E, Nelson, Chad, Tan, Choon Ping, Schaller, Torsten, Lehner, Paul J, Sundquist, Wesley I, Towers, Greg J
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Ltd 2015
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551353/
https://ncbi.nlm.nih.gov/pubmed/26101372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490361
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