Targeted diphtheria toxin to treat BPDCN

Por FitzGerald, David J.
Publicado em 2014

The Insulin Receptor Negatively Regulates the Action of Pseudomonas Toxin-Based Immunotoxins and Native Pseudomonas Toxin

Por Liu, Xiu Fen, FitzGerald, David J., Pastan, Ira
Publicado em 2013

Differential Cellular Internalization of Anti-CD19 and CD22 Immunotoxins Results in Different Cytotoxic Activity

Por Du, Xing, Beers, Richard, FitzGerald, David J., Pastan, Ira
Publicado em 2008

Phase I Trial of Continuous Infusion Anti-Mesothelin Recombinant Immunotoxin SS1P

Por Kreitman, Robert J., Hassan, Raffit, FitzGerald, David J., Pastan, Ira
Publicado em 2009

Pseudomonas Exotoxin A-Mediated Apoptosis Is Bak Dependent and Preceded by the Degradation of Mcl-1

Por Du, Xing, Youle, Richard J., FitzGerald, David J., Pastan, Ira
Publicado em 2010

Treatment of Hematologic Malignancies with Immunotoxins and Antibody-drug Conjugates

Por FitzGerald, David J., Wayne, Alan S., Kreitman, Robert J., Pastan, Ira
Publicado em 2011

Antitumor Effects of Immunotoxins are Enhanced by Lowering HCK or Treatment with Src Kinase Inhibitors

Por Liu, Xiu-Fen, Xiang, Laiman, FitzGerald, David J., Pastan, Ira
Publicado em 2013

Immunotoxins for leukemia

Por Wayne, Alan S., FitzGerald, David J., Kreitman, Robert J., Pastan, Ira
Publicado em 2014

Enhanced Macrophage Resistance to Pseudomonas Exotoxin A Is Correlated with Decreased Expression of the Low-Density Lipoprotein Receptor-Related Protein

Por Laithwaite, James E., Benn, Sally J., Yamate, Jyoji, FitzGerald, David J., LaMarre, Jonathan
Publicado em 1999

Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy

Por Wei, Hui, Xiang, Laiman, Wayne, Alan S., Chertov, Oleg, FitzGerald, David J., Bera, Tapan K., Pastan, Ira
Publicado em 2012

A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity

Por Weldon, John E., Xiang, Laiman, Chertov, Oleg, Margulies, Inger, Kreitman, Robert J., FitzGerald, David J., Pastan, Ira
Publicado em 2009

Proteolytic Cleavage of a C-terminal Prosequence, Leading to Autoprocessing at the N Terminus, Activates Leucine Aminopeptidase from Pseudomonas aeruginosa

Por Sarnovsky, Robert, Rea, Jennifer, Makowski, Matt, Hertle, Ralf, Kelly, Colleen, Antignani, Antonella, Pastrana, Diana V., FitzGerald, David J.
Publicado em 2009

ABT-737 overcomes resistance to immunotoxin-mediated apoptosis and enhances the delivery of Pseudomonas Exotoxin-based proteins to the cell cytosol

Por Traini, Roberta, Ben-Josef, Gal, Pastrana, Diana V., Moskatel, Elizabeth, Sharma, Ashima K., Antignani, Antonella, FitzGerald, David J.
Publicado em 2010

Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity

Por Pasetto, Matteo, Antignani, Antonella, Ormanoglu, Pinar, Buehler, Eugen, Guha, Rajarshi, Pastan, Ira, Martin, Scott E., FitzGerald, David J.
Publicado no Proc Natl Acad Sci U S A (2015)

Anticancer Effects of Mesothelin-targeted Immunotoxin Therapy are Regulated by Tyrosine Kinase DDR1

Por Ali-Rahmani, Fatima, FitzGerald, David J., Martin, Scott, Patel, Paresma, Prunotto, Marco, Ormanoglu, Pinar, Thomas, Craig, Pastan, Ira
Publicado no Cancer Res (2015)

Phase II Trial of Recombinant Immunotoxin RFB4(dsFv)-PE38 (BL22) in Patients With Hairy Cell Leukemia

Por Kreitman, Robert J., Stetler-Stevenson, Maryalice, Margulies, Inger, Noel, Pierre, FitzGerald, David J.P., Wilson, Wyndham H., Pastan, Ira
Publicado em 2009

Tofacitinib Suppresses Antibody Responses to Protein Therapeutics in Murine Hosts()

Por Onda, Masanori, Ghoreschi, Kamran, Steward-Tharp, Scott, Thomas, Craig, O’Shea, John J., Pastan, Ira H., FitzGerald, David J.
Publicado em 2014

Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis

Por Wilderman, Paula J., Sowa, Nathaniel A., FitzGerald, David J., FitzGerald, Peter C., Gottesman, Susan, Ochsner, Urs A., Vasil, Michael L.
Publicado em 2004

Phase I Trial of Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox (CAT-8015 or HA22) in Patients With Hairy Cell Leukemia

Por Kreitman, Robert J., Tallman, Martin S., Robak, Tadeusz, Coutre, Steven, Wilson, Wyndham H., Stetler-Stevenson, Maryalice, FitzGerald, David J., Lechleider, Robert, Pastan, Ira
Publicado em 2012

Anti-CD22 Immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22 Positive Hematologic Malignancies of Childhood: Pre-clinical Studies and Phase I Clinical Trial

Por Wayne, Alan S., Kreitman, Robert J., Findley, Harry W., Lew, Glen, Delbrook, Cynthia, Steinberg, Seth M., Stetler-Stevenson, Maryalice, FitzGerald, David J., Pastan, Ira
Publicado em 2010