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Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy

HA22 is a recombinant immunotoxin composed of an anti-CD22 Fv fused to a portion of Pseudomonas exotoxin A. HA22 produced a high rate of complete remissions in drug-resistant hairy cell leukemia and has a lower response rate in pediatric acute lymphoblastic leukemia (ALL). To understand why patients...

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Detalhes bibliográficos
Main Authors: Wei, Hui, Xiang, Laiman, Wayne, Alan S., Chertov, Oleg, FitzGerald, David J., Bera, Tapan K., Pastan, Ira
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345006/
https://ncbi.nlm.nih.gov/pubmed/22509046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204523109
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