A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene

HA22 is a recombinant immunotoxin that kills CD22-expressing cells by ADP-ribosylating and inactivating elongation factor-2 (EF2). HA22 is composed of an Fv that binds to CD22 fused to a portion of Pseudomonas exotoxin A. HA22 is very active in drug-resistant hairy cell leukemia but is less active i...

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Bibliografske podrobnosti
Main Authors: Wei, Hui, Bera, Tapan K., Wayne, Alan S., Xiang, Laiman, Colantonio, Simona, Chertov, Oleg, Pastan, Ira
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636914/
https://ncbi.nlm.nih.gov/pubmed/23486472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.461343
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