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Antitumor Effects of Immunotoxins are Enhanced by Lowering HCK or Treatment with Src Kinase Inhibitors

Recombinant immunotoxins (RITs) are agents being developed for cancer treatment. They are composed of an Fv that binds to a cancer cell, fused to a 38-kDa fragment of Pseudomonas exotoxin A. SS1P is a RIT that targets mesothelin, a protein expressed on mesothelioma as well as pancreatic, ovarian, lu...

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Bibliografske podrobnosti
Main Authors: Liu, Xiu-Fen, Xiang, Laiman, FitzGerald, David J., Pastan, Ira
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947114/
https://ncbi.nlm.nih.gov/pubmed/24145282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0726
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