Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity

Immunotoxins (antibody–toxin fusion proteins) target surface antigens on cancer cells and kill these cells via toxin-mediated inhibition of protein synthesis. To identify genes controlling this process, an RNAi whole-genome screen (∼22,000 genes at three siRNAs per gene) was conducted via monitoring...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Pasetto, Matteo, Antignani, Antonella, Ormanoglu, Pinar, Buehler, Eugen, Guha, Rajarshi, Pastan, Ira, Martin, Scott E., FitzGerald, David J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364196/
https://ncbi.nlm.nih.gov/pubmed/25713356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501958112
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