Therapeutically targeting guanylate cyclase‐C: computational modeling of plecanatide, a uroguanylin analog

von Brancale, Andrea, Shailubhai, Kunwar, Ferla, Salvatore, Ricci, Antonio, Bassetto, Marcella, Jacob, Gary S
Veröffentlicht in Pharmacol Res Perspect (2017)

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

von Padalino, Gilda, Ferla, Salvatore, Brancale, Andrea, Chalmers, Iain W., Hoffmann, Karl F.
Veröffentlicht in Int J Parasitol Drugs Drug Resist (2018)

Erratum to ‘Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni’ [IJP Drugs...

von Padalino, Gilda, Ferla, Salvatore, Brancale, Andrea, Chalmers, Iain W., Hoffmann, Karl F.
Veröffentlicht in Int J Parasitol Drugs Drug Resist (2019)

Rational design and synthesis of novel phenylsulfonyl-benzamides as anti-prostate cancer agents

von Bassetto, Marcella, Ferla, Salvatore, Giancotti, Gilda, Pertusati, Fabrizio, Westwell, Andrew D., Brancale, Andrea, McGuigan, Christopher
Veröffentlicht in Medchemcomm (2017)

Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents

von Bassetto, Marcella, Ferla, Salvatore, Leyssen, Pieter, Neyts, Johan, Yerukhimovich, Mark M, Frick, David N, O’Donnell, Rachel, Brancale, Andrea
Veröffentlicht in Antivir Chem Chemother (2016)

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replicat...

von Płaszczyca, Anna, Scaturro, Pietro, Neufeldt, Christopher John, Cortese, Mirko, Cerikan, Berati, Ferla, Salvatore, Brancale, Andrea, Pichlmair, Andreas, Bartenschlager, Ralf
Veröffentlicht in PLoS Pathog (2019)

A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase

von Giancotti, Gilda, Rigo, Ilaria, Pasqualetto, Gaia, Young, Mark T., Neyts, Johan, Rocha-Pereira, Joana, Brancale, Andrea, Ferla, Salvatore, Bassetto, Marcella
Veröffentlicht in Sci Rep (2019)

Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

von Flude, Ben M., Nannetti, Giulio, Mitchell, Paige, Compton, Nina, Richards, Chloe, Heurich, Meike, Brancale, Andrea, Ferla, Salvatore, Bassetto, Marcella
Veröffentlicht in Viruses (2021)

In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase

von Ferla, Salvatore, Netzler, Natalie E., Ferla, Sebastiano, Veronese, Sofia, Tuipulotu, Daniel Enosi, Guccione, Salvatore, Brancale, Andrea, White, Peter A., Bassetto, Marcella
Veröffentlicht in Sci Rep (2018)

Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents

von Oliva, Paola, Onnis, Valentina, Balboni, Elisa, Hamel, Ernest, Estévez-Sarmiento, Francisco, Quintana, José, Estévez, Francisco, Brancale, Andrea, Ferla, Salvatore, Manfredini, Stefano, Romagnoli, Romeo
Veröffentlicht in Molecules (2020)

Computational Studies towards the Identification of Novel Rhodopsin-Binding Compounds as Chemical Chaperones for Misfolded Opsins

von Pasqualetto, Gaia, Schepelmann, Martin, Varricchio, Carmine, Pileggi, Elisa, Khogali, Caroline, Morgan, Siân R., Boostrom, Ian, Rozanowska, Malgorzata, Brancale, Andrea, Ferla, Salvatore, Bassetto, Marcella
Veröffentlicht in Molecules (2020)

Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3′,4′,5′-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold

von Romagnoli, Romeo, Prencipe, Filippo, Oliva, Paola, Cacciari, Barbara, Balzarini, Jan, Liekens, Sandra, Hamel, Ernest, Brancale, Andrea, Ferla, Salvatore, Manfredini, Stefano, Zurlo, Matteo, Finotti, Alessia, Gambari, Roberto
Veröffentlicht in Molecules (2020)

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

von Whatley, Kezia C. L., Padalino, Gilda, Whiteland, Helen, Geyer, Kathrin K., Hulme, Benjamin J., Chalmers, Iain W., Forde-Thomas, Josephine, Ferla, Salvatore, Brancale, Andrea, Hoffmann, Karl F.
Veröffentlicht in PLoS Negl Trop Dis (2019)

Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection

von Albulescu, Irina C., White-Scholten, Leonie, Tas, Ali, Hoornweg, Tabitha E., Ferla, Salvatore, Kovacikova, Kristina, Smit, Jolanda M., Brancale, Andrea, Snijder, Eric J., van Hemert, Martijn J.
Veröffentlicht in Viruses (2020)

Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3′,4′,5′-Trimethoxyphenyl)-2-Aryl-1H-Imidazole

von Romagnoli, Romeo, Baraldi, Pier Giovanni, Prencipe, Filippo, Oliva, Paola, Baraldi, Stefania, Tabrizi, Mojgan Aghazadeh, Lopez-Cara, Luisa Carlota, Ferla, Salvatore, Brancale, Andrea, Hamel, Ernest, Ronca, Roberto, Bortolozzi, Roberta, Mariotto, Elena, Basso, Giuseppe, Viola, Giampietro
Veröffentlicht in Sci Rep (2016)

2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition

von Romagnoli, Romeo, Salvador, Maria Kimatrai, Ortega, Santiago Schiaffino, Baraldi, Pier Giovanni, Oliva, Paola, Baraldi, Stefania, Lopez-Cara, Luisa Carlota, Brancale, Andrea, Ferla, Salvatore, Hamel, Ernest, Balzarini, Jan, Liekens, Sandra, Mattiuzzo, Elena, Basso, Giuseppe, Viola, Giampietro
Veröffentlicht in Eur J Med Chem (2018)

Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents

von Romagnoli, Romeo, Baraldi, Pier Giovanni, Prencipe, Filippo, Oliva, Paola, Baraldi, Stefania, Salvador, Maria Kimatrai, Lopez-Cara, Luisa Carlota, Brancale, Andrea, Ferla, Salvatore, Hamel, Ernest, Ronca, Roberto, Bortolozzi, Roberta, Mariotto, Elena, Porcù, Elena, Basso, Giuseppe, Viola, Giampietro
Veröffentlicht in Sci Rep (2017)

Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C

von Bauer, Lisa, Manganaro, Roberto, Zonsics, Birgit, Hurdiss, Daniel L., Zwaagstra, Marleen, Donselaar, Tim, Welter, Naemi G. E., van Kleef, Regina G. D. M., Lopez, Moira Lorenzo, Bevilacqua, Federica, Raman, Thamidur, Ferla, Salvatore, Bassetto, Marcella, Neyts, Johan, Strating, Jeroen R. P. M., Westerink, Remco H. S., Brancale, Andrea, van Kuppeveld, Frank J. M.
Veröffentlicht in PLoS Biol (2020)

Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis

von Lauder, Sarah N., Allen-Redpath, Keith, Slatter, David A., Aldrovandi, Maceler, O’Connor, Anne, Farewell, Daniel, Percy, Charles L., Molhoek, Jessica E., Rannikko, Sirpa, Tyrrell, Victoria J., Ferla, Salvatore, Milne, Ginger L., Poole, Alastair W., Thomas, Christopher P., Obaji, Samya, Taylor, Philip R., Jones, Simon A., de Groot, Phillip G., Urbanus, Rolf T., Hörkkö, Sohvi, Uderhardt, Stefan, Ackermann, Jochen, Jenkins, P. Vince, Brancale, Andrea, Krönke, Gerhard, Collins, Peter W., O’Donnell, Valerie B.
Veröffentlicht in Sci Signal (2017)