Therapeutically targeting guanylate cyclase‐C: computational modeling of plecanatide, a uroguanylin analog

Plecanatide is a recently developed guanylate cyclase‐C (GC‐C) agonist and the first uroguanylin analog designed to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS‐C). GC‐C receptors are found across the length of the intestines and are thought to play...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Brancale, Andrea, Shailubhai, Kunwar, Ferla, Salvatore, Ricci, Antonio, Bassetto, Marcella, Jacob, Gary S
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368960/
https://ncbi.nlm.nih.gov/pubmed/28357122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.295
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