Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc(+/Min-FCCC) mice

AIM: To evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc(+/Min-FCCC) mice with dextran sodium sulfate (DSS)-induced inflammation. METHODS: Inflammation driven colorectal carcinogenesis was induced in Apc(+/Min-FCCC) mice by administering DSS in their drinking wat...

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Detalhes bibliográficos
Publicado no:World J Gastrointest Pharmacol Ther
Main Authors: Chang, Wen-Chi L, Masih, Shet, Thadi, Anusha, Patwa, Viren, Joshi, Apoorva, Cooper, Harry S, Palejwala, Vaseem A, Clapper, Margie L, Shailubhai, Kunwar
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2017
Assuntos:
Basic Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292606/
https://ncbi.nlm.nih.gov/pubmed/28217374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4292/wjgpt.v8.i1.47
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