Therapeutically targeting guanylate cyclase‐C: computational modeling of plecanatide, a uroguanylin analog

Plecanatide is a recently developed guanylate cyclase‐C (GC‐C) agonist and the first uroguanylin analog designed to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS‐C). GC‐C receptors are found across the length of the intestines and are thought to play...

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Bibliografische gegevens
Gepubliceerd in:Pharmacol Res Perspect
Hoofdauteurs: Brancale, Andrea, Shailubhai, Kunwar, Ferla, Salvatore, Ricci, Antonio, Bassetto, Marcella, Jacob, Gary S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2017
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368960/
https://ncbi.nlm.nih.gov/pubmed/28357122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.295
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