Therapeutically targeting guanylate cyclase‐C: computational modeling of plecanatide, a uroguanylin analog

Plecanatide is a recently developed guanylate cyclase‐C (GC‐C) agonist and the first uroguanylin analog designed to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS‐C). GC‐C receptors are found across the length of the intestines and are thought to play...

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Bibliografiske detaljer
Udgivet i:Pharmacol Res Perspect
Main Authors: Brancale, Andrea, Shailubhai, Kunwar, Ferla, Salvatore, Ricci, Antonio, Bassetto, Marcella, Jacob, Gary S
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368960/
https://ncbi.nlm.nih.gov/pubmed/28357122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.295
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