2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition

Microtubules are recognized as crucial components of the mitotic spindle during cell division, and, for this reason, the microtubule system is an attractive target for the development of anticancer agents. Continuing our search strategy for novel tubulin targeting-compounds, a new series of 2-alkoxy...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Romagnoli, Romeo, Salvador, Maria Kimatrai, Ortega, Santiago Schiaffino, Baraldi, Pier Giovanni, Oliva, Paola, Baraldi, Stefania, Lopez-Cara, Luisa Carlota, Brancale, Andrea, Ferla, Salvatore, Hamel, Ernest, Balzarini, Jan, Liekens, Sandra, Mattiuzzo, Elena, Basso, Giuseppe, Viola, Giampietro
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791907/
https://ncbi.nlm.nih.gov/pubmed/29220790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.11.096
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