Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis

Blood coagulation functions as part of the innate immune system by preventing bacterial invasion and it is critical to stopping blood loss (hemostasis). Coagulation involves the external membrane surface of activated platelets and leukocytes. Using lipidomic, genetic, biochemical, and mathematical m...

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Publicat a:Sci Signal
Autors principals: Lauder, Sarah N., Allen-Redpath, Keith, Slatter, David A., Aldrovandi, Maceler, O’Connor, Anne, Farewell, Daniel, Percy, Charles L., Molhoek, Jessica E., Rannikko, Sirpa, Tyrrell, Victoria J., Ferla, Salvatore, Milne, Ginger L., Poole, Alastair W., Thomas, Christopher P., Obaji, Samya, Taylor, Philip R., Jones, Simon A., de Groot, Phillip G., Urbanus, Rolf T., Hörkkö, Sohvi, Uderhardt, Stefan, Ackermann, Jochen, Jenkins, P. Vince, Brancale, Andrea, Krönke, Gerhard, Collins, Peter W., O’Donnell, Valerie B.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720345/
https://ncbi.nlm.nih.gov/pubmed/29184033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aan2787
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