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In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase
Human norovirus causes approximately 219,000 deaths annually, yet there are currently no antivirals available. A virtual screening of commercially available drug-like compounds (~300,000) was performed on the suramin and PPNDS binding-sites of the norovirus RNA-dependent RNA polymerase (RdRp). Selec...
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| Vydáno v: | Sci Rep |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5841303/ https://ncbi.nlm.nih.gov/pubmed/29515206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22303-y |
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