Pathogenic Germline Variants in Patients With Metastatic Breast Cancer

by Stuttgen, Kelsey, Croessmann, Sarah, Fetting, John, Stearns, Vered, Nunes, Raquel, Connolly, Roisin M., Park, Ben Ho
Published in JAMA Oncol (2019)

PIK3CA C2 domain deletions hyperactivate phosphoinositide 3-kinase (PI3K), generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors

by Croessmann, Sarah, Sheehan, Jonathan H., Lee, Kyung-min, Sliwoski, Gregory, He, Jie, Nagy, Rebecca, Riddle, David, Mayer, Ingrid, Balko, Justin M., Lanman, Richard, Miller, Vincent A., Cantley, Lewis C., Meiler, Jens, Arteaga, Carlos L.
Published in Clin Cancer Res (2017)

Analysis of BRCA2 loss-of-heterozygosity in tumor tissue using droplet digital PCR

by Cochran, Rory L., Cravero, Karen, Chu, David, Erlanger, Bracha, Toro, Patricia Valda, Beaver, Julia A., Zabransky, Daniel J., Wong, Hong Yuen, Cidado, Justin, Croessmann, Sarah, Parsons, Heather, Kim, Minsoo, Wheelan, Sarah J., Argani, Pedram, Ho Park, Ben
Published 2014

Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes

by Cochran, Rory L., Cidado, Justin, Kim, Minsoo, Zabransky, Daniel J., Croessmann, Sarah, Chu, David, Wong, Hong Yuen, Beaver, Julia A., Cravero, Karen, Erlanger, Bracha, Parsons, Heather, Heaphy, Christopher M., Meeker, Alan K., Lauring, Josh, Park, Ben Ho
Published in Oncotarget (2015)

Whole exome sequencing of metaplastic breast carcinoma indicates monoclonality with associated ductal carcinoma component

by Avigdor, Bracha Erlanger, Beierl, Katie, Gocke, Christopher D, Zabransky, Daniel J, Cravero, Karen, Kyker-Snowman, Kelly, Button, Berry, Chu, David, Croessmann, Sarah, Cochran, Rory L, Connolly, Roisin M, Park, Ben H, Cimino-Mathews, Ashley, Wheelan, Sarah J
Published in Clin Cancer Res (2017)

A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations

by Blair, Brian G., Wu, Xinyan, Zahari, Muhammad Saddiq, Mohseni, Morassa, Cidado, Justin, Wong, Hong Yuen, Beaver, Julia A., Cochran, Rory L., Zabransky, Daniel J., Croessmann, Sarah, Chu, David, Toro, Patricia Valda, Cravero, Karen, Pandey, Akhilesh, Park, Ben Ho
Published in Proteomics (2014)

PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity

by Croessmann, Sarah, Wong, Hong Yuen, Zabransky, Daniel J., Chu, David, Rosen, D. Marc, Cidado, Justin, Cochran, Rory L., Dalton, W. Brian, Erlanger, Bracha, Cravero, Karen, Button, Berry, Kyker-Snowman, Kelly, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Published in Breast Cancer Res Treat (2017)

TrkA overexpression in non-tumorigenic human breast cell lines confers oncogenic and metastatic properties.

by Kyker-Snowman, Kelly, Hughes, Robert M., Yankaskas, Christopher L., Cravero, Karen, Karthikeyan, Swathi, Button, Berry, Waters, Ian, Rosen, David Marc, Dennison, Lauren, Hunter, Natasha, Donaldson, Josh, Christenson, Eric S., Konstantopoulos, Konstantinos, Hurley, Paula J., Croessmann, Sarah, Park, Ben Ho
Published in Breast Cancer Res Treat (2019)

Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA

by Toro, Patricia Valda, Erlanger, Bracha, Beaver, Julia A., Cochran, Rory L., VanDenBerg, Dustin A., Yakim, Elizabeth, Cravero, Karen, Chu, David, Zabransky, Daniel J., Wong, Hong Yuen, Croessmann, Sarah, Parsons, Heather, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Published in Clin Biochem (2015)

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer

by Wong, Hong Yuen, Wang, Grace M., Croessmann, Sarah, Zabransky, Daniel J., Chu, David, Garay, Joseph P., Cidado, Justin, Cochran, Rory L., Beaver, Julia A., Aggarwal, Anita, Liu, Min-Ling, Argani, Pedram, Meeker, Alan, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Published in Oncotarget (2015)

Extended adjuvant therapy with neratinib plus fulvestrant blocks ER/HER2 crosstalk and maintains complete responses of ER+/HER2+ breast cancers: Implications to the ExteNET trial

by Sudhan, Dhivya R., Schwarz, Luis J., Guerrero-Zotano, Angel, Formisano, Luigi, Nixon, Mellissa, Croessmann, Sarah, Ericsson, Paula I. González, Sanders, Melinda E., Balko, Justin M., Avogadri-Connors, Francesca, Cutler, Richard E., Lalani, Alshad S., Bryce, Richard, Auerbach, Alan, Arteaga, Carlos L.
Published in Clin Cancer Res (2018)

Combined blockade of activating ERBB2 mutations and ER results in synthetic lethality of ER+/HER2 mutant breast cancer

by Croessmann, Sarah, Formisano, Luigi, Kinch, Lisa N., Gonzalez-Ericsson, Paula I., Sudhan, Dhivya R., Nagy, Rebecca J., Mathew, Aju, Bernicker, Eric H., Cristofanilli, Massimo, He, Jie, Cutler, Richard E., Lalani, Alshad S., Miller, Vincent A., Lanman, Richard B., Grishin, Nick V., Arteaga, Carlos L.
Published in Clin Cancer Res (2018)

The estrogen receptor-alpha S118P variant does not affect breast cancer incidence or response to endocrine therapies

by Button, Berry, Croessmann, Sarah, Chu, David, Rosen, D. Marc, Zabransky, Dan J., Dalton, W. Brian, Cravero, Karen, Kyker-Snowman, Kelly, Waters, Ian, Karthikeyan, Swathi, Christenson, Eric, Donaldson, Josh, Hunter, Tasha, Dennison, Lauren, Ramin, Cody, May, Betty, Roden, Richard, Petry, Dana, Armstrong, Deborah K., Visvanathan, Kala, Park, Ben Ho
Published in Breast Cancer Res Treat (2018)

MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers

by Mohseni, Morassa, Cidado, Justin, Croessmann, Sarah, Cravero, Karen, Cimino-Mathews, Ashley, Wong, Hong Yuen, Scharpf, Rob, Zabransky, Daniel J., Abukhdeir, Abde M., Garay, Joseph P., Wang, Grace M., Beaver, Julia A., Cochran, Rory L., Blair, Brian G., Rosen, D. Marc, Erlanger, Bracha, Argani, Pedram, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Published in Proc Natl Acad Sci U S A (2014)

NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability

by Croessmann, Sarah, Wong, Hong Yuen, Zabransky, Daniel J., Chu, David, Mendonca, Janet, Sharma, Anup, Mohseni, Morassa, Rosen, D. Marc, Scharpf, Robert B., Cidado, Justin, Cochran, Rory L., Parsons, Heather A., Dalton, W. Brian, Erlanger, Bracha, Button, Berry, Cravero, Karen, Kyker-Snowman, Kelly, Beaver, Julia A., Kachhap, Sushant, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Published in Proc Natl Acad Sci U S A (2015)

Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation

by Wang, Grace M., Wong, Hong-Yuen, Konishi, Hiroyuki, Blair, Brian G., Abukhdeir, Abde, Gustin, John P., Rosen, D. Marc, Denmeade, Samuel, Rasheed, Zeshaan, Matsui, William, Garay, Joseph P., Mohseni, Morassa, Higgins, Michaela J., Cidado, Justin, Jelovac, Danijela, Croessmann, Sarah, Cochran, Rory, Karnan, Sivasundaram, Konishi, Yuko, Ota, Akinobu, Hosokawa, Yoshitaka, Argani, Pedram, Lauring, Josh, Park, Ben Ho
Published 2013

Hierarchical tumor heterogeneity mediated by cell contact between distinct genetic subclones

by Karthikeyan, Swathi, Waters, Ian G., Dennison, Lauren, Chu, David, Donaldson, Joshua, Shin, Dong Ho, Rosen, D. Marc, Gonzalez-Ericsson, Paula I., Sanchez, Violeta, Sanders, Melinda E., Pantone, Morgan V., Bergman, Riley E., Davidson, Brad A., Reed, Sarah C., Zabransky, Daniel J., Cravero, Karen, Kyker-Snowman, Kelly, Button, Berry, Wong, Hong Yuen, Hurley, Paula J., Croessmann, Sarah, Park, Ben Ho
Published in J Clin Invest (2021)

HER2 missense mutations have distinct effects on oncogenic signaling and migration

by Zabransky, Daniel J., Yankaskas, Christopher L., Cochran, Rory L., Wong, Hong Yuen, Croessmann, Sarah, Chu, David, Kavuri, Shyam M., Red Brewer, Monica, Rosen, D. Marc, Dalton, W. Brian, Cimino-Mathews, Ashley, Cravero, Karen, Button, Berry, Kyker-Snowman, Kelly, Cidado, Justin, Erlanger, Bracha, Parsons, Heather A., Manto, Kristen M., Bose, Ron, Lauring, Josh, Arteaga, Carlos L., Konstantopoulos, Konstantinos, Park, Ben Ho
Published in Proc Natl Acad Sci U S A (2015)

Ki-67 is required for maintenance of cancer stem cells but not cell proliferation

by Cidado, Justin, Wong, Hong Yuen, Rosen, D. Marc, Cimino-Mathews, Ashley, Garay, Joseph P., Fessler, Abigail G., Rasheed, Zeshaan A., Hicks, Jessica, Cochran, Rory L., Croessmann, Sarah, Zabransky, Daniel J., Mohseni, Morassa, Beaver, Julia A., Chu, David, Cravero, Karen, Christenson, Eric S., Medford, Arielle, Mattox, Austin, De Marzo, Angelo M., Argani, Pedram, Chawla, Ajay, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Published in Oncotarget (2016)

Detection of Cancer DNA in Plasma of Early Stage Breast Cancer Patients

by Beaver, Julia A., Jelovac, Danijela, Balukrishna, Sasidharan, Cochran, Rory, Croessmann, Sarah, Zabransky, Daniel J., Wong, Hong Yuen, Toro, Patricia Valda, Cidado, Justin, Blair, Brian G., Chu, David, Burns, Timothy, Higgins, Michaela J., Stearns, Vered, Jacobs, Lisa, Habibi, Mehran, Lange, Julie, Hurley, Paula J., Lauring, Josh, VanDenBerg, Dustin, Kessler, Jill, Jeter, Stacie, Samuels, Michael L., Maar, Dianna, Cope, Leslie, Cimino-Mathews, Ashley, Argani, Pedram, Wolff, Antonio C., Park, Ben H.
Published 2014