Hierarchical tumor heterogeneity mediated by cell contact between distinct genetic subclones

Intratumor heterogeneity is an important mediator of poor outcomes in many cancers, including breast cancer. Genetic subclones frequently contribute to this heterogeneity; however, their growth dynamics and interactions remain poorly understood. PIK3CA and HER2 alterations are known to coexist in br...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Karthikeyan, Swathi, Waters, Ian G., Dennison, Lauren, Chu, David, Donaldson, Joshua, Shin, Dong Ho, Rosen, D. Marc, Gonzalez-Ericsson, Paula I., Sanchez, Violeta, Sanders, Melinda E., Pantone, Morgan V., Bergman, Riley E., Davidson, Brad A., Reed, Sarah C., Zabransky, Daniel J., Cravero, Karen, Kyker-Snowman, Kelly, Button, Berry, Wong, Hong Yuen, Hurley, Paula J., Croessmann, Sarah, Park, Ben Ho
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954606/
https://ncbi.nlm.nih.gov/pubmed/33529175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143557
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