The estrogen receptor-alpha S118P variant does not affect breast cancer incidence or response to endocrine therapies

PURPOSE: Estrogen receptor-alpha (ER) is a therapeutic target of ER positive (ER+) breast cancers. Although ER signaling is complex, many mediators of this pathway have been identified. Specifically, phosphorylation of ER at serine 118 affects responses to estrogen and therapeutic ligands and has be...

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Publicado no:Breast Cancer Res Treat
Main Authors: Button, Berry, Croessmann, Sarah, Chu, David, Rosen, D. Marc, Zabransky, Dan J., Dalton, W. Brian, Cravero, Karen, Kyker-Snowman, Kelly, Waters, Ian, Karthikeyan, Swathi, Christenson, Eric, Donaldson, Josh, Hunter, Tasha, Dennison, Lauren, Ramin, Cody, May, Betty, Roden, Richard, Petry, Dana, Armstrong, Deborah K., Visvanathan, Kala, Park, Ben Ho
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447053/
https://ncbi.nlm.nih.gov/pubmed/30560461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-018-05087-7
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