TrkA overexpression in non-tumorigenic human breast cell lines confers oncogenic and metastatic properties.

BACKGROUND/PURPOSE: TrkA overexpression occurs in over 20% of breast cancers, including triple-negative breast cancers (TNBC), and has recently been recognized as a potential driver of carcinogenesis. Recent clinical trials of pan-Trk inhibitors have demonstrated targeted activity against tumors har...

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Veröffentlicht in:Breast Cancer Res Treat
Hauptverfasser: Kyker-Snowman, Kelly, Hughes, Robert M., Yankaskas, Christopher L., Cravero, Karen, Karthikeyan, Swathi, Button, Berry, Waters, Ian, Rosen, David Marc, Dennison, Lauren, Hunter, Natasha, Donaldson, Josh, Christenson, Eric S., Konstantopoulos, Konstantinos, Hurley, Paula J., Croessmann, Sarah, Park, Ben Ho
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337566/
https://ncbi.nlm.nih.gov/pubmed/31823098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-019-05506-3
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