GIPC Is Recruited by APPL to Peripheral TrkA Endosomes and Regulates TrkA Trafficking and Signaling

GIPC is a PDZ protein located on peripheral endosomes that binds to the juxtamembrane region of the TrkA nerve growth factor (NGF) receptor and has been implicated in NGF signaling. We establish here that endogenous GIPC binds to the C terminus of APPL, a Rab5 binding protein, which is a marker for...

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Detalhes bibliográficos
Main Authors: Varsano, Tal, Dong, Meng-Qiu, Niesman, Ingrid, Gacula, Hyacynth, Lou, Xiaojing, Ma, Tianlin, Testa, Joseph R., Yates, John R., Farquhar, Marilyn G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636811/
https://ncbi.nlm.nih.gov/pubmed/17015470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00305-06
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