APPL1 Associates with TrkA and GIPC1 and Is Required for Nerve Growth Factor-Mediated Signal Transduction

The neurotrophin receptor TrkA plays critical roles in the nervous system by recruiting signaling molecules that activate pathways required for the growth and survival of neurons. Here, we report APPL1 as a TrkA-associated protein. APPL1 and TrkA coimmunoprecipitated in sympathetic neurons. We have...

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Autors principals: Lin, Dan C., Quevedo, Celia, Brewer, Natalie E., Bell, Alex, Testa, Joseph R., Grimes, Mark L., Miller, Freda D., Kaplan, David R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636815/
https://ncbi.nlm.nih.gov/pubmed/17000777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00228-06
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