SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase

Nerve growth factor (NGF) mediates the survival and differentiation of neurons by stimulating the tyrosine kinase activity of the TrkA/NGF receptor. Here, we identify SHP-1 as a phosphotyrosine phosphatase that negatively regulates TrkA. SHP-1 formed complexes with TrkA at Y490, and dephosphorylated...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Marsh, H. Nicholas, Dubreuil, Catherine I., Quevedo, Celia, Lee, Anna, Majdan, Marta, Walsh, Gregory S., Hausdorff, Sharon, Said, Farid Arab, Zoueva, Olga, Kozlowski, Maya, Siminovitch, Katherine, Neel, Benjamin G., Miller, Freda D., Kaplan, David R.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2003
主題:
Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173621/
https://ncbi.nlm.nih.gov/pubmed/14662744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200309036
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍