SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase

Nerve growth factor (NGF) mediates the survival and differentiation of neurons by stimulating the tyrosine kinase activity of the TrkA/NGF receptor. Here, we identify SHP-1 as a phosphotyrosine phosphatase that negatively regulates TrkA. SHP-1 formed complexes with TrkA at Y490, and dephosphorylated...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Marsh, H. Nicholas, Dubreuil, Catherine I., Quevedo, Celia, Lee, Anna, Majdan, Marta, Walsh, Gregory S., Hausdorff, Sharon, Said, Farid Arab, Zoueva, Olga, Kozlowski, Maya, Siminovitch, Katherine, Neel, Benjamin G., Miller, Freda D., Kaplan, David R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2003
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173621/
https://ncbi.nlm.nih.gov/pubmed/14662744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200309036
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