Llwytho...
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
Nerve growth factor (NGF) mediates the survival and differentiation of neurons by stimulating the tyrosine kinase activity of the TrkA/NGF receptor. Here, we identify SHP-1 as a phosphotyrosine phosphatase that negatively regulates TrkA. SHP-1 formed complexes with TrkA at Y490, and dephosphorylated...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , , , , , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
The Rockefeller University Press
2003
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173621/ https://ncbi.nlm.nih.gov/pubmed/14662744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200309036 |
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