SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase

Nerve growth factor (NGF) mediates the survival and differentiation of neurons by stimulating the tyrosine kinase activity of the TrkA/NGF receptor. Here, we identify SHP-1 as a phosphotyrosine phosphatase that negatively regulates TrkA. SHP-1 formed complexes with TrkA at Y490, and dephosphorylated...

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Detalhes bibliográficos
Main Authors: Marsh, H. Nicholas, Dubreuil, Catherine I., Quevedo, Celia, Lee, Anna, Majdan, Marta, Walsh, Gregory S., Hausdorff, Sharon, Said, Farid Arab, Zoueva, Olga, Kozlowski, Maya, Siminovitch, Katherine, Neel, Benjamin G., Miller, Freda D., Kaplan, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173621/
https://ncbi.nlm.nih.gov/pubmed/14662744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200309036
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