TrkA overexpression in non-tumorigenic human breast cell lines confers oncogenic and metastatic properties.

BACKGROUND/PURPOSE: TrkA overexpression occurs in over 20% of breast cancers, including triple-negative breast cancers (TNBC), and has recently been recognized as a potential driver of carcinogenesis. Recent clinical trials of pan-Trk inhibitors have demonstrated targeted activity against tumors har...

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Vydáno v:Breast Cancer Res Treat
Hlavní autoři: Kyker-Snowman, Kelly, Hughes, Robert M., Yankaskas, Christopher L., Cravero, Karen, Karthikeyan, Swathi, Button, Berry, Waters, Ian, Rosen, David Marc, Dennison, Lauren, Hunter, Natasha, Donaldson, Josh, Christenson, Eric S., Konstantopoulos, Konstantinos, Hurley, Paula J., Croessmann, Sarah, Park, Ben Ho
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337566/
https://ncbi.nlm.nih.gov/pubmed/31823098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-019-05506-3
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