Nutrient-responsive mTOR signalling grows on Sterile ground

Por Cook, Simon J., Morley, Simon J.
Publicado em 2007

That which does not kill me makes me stronger; combining ERK1/2 pathway inhibitors and BH3 mimetics to kill tumour cells and prevent acquired resistance

Por Sale, Matthew J, Cook, Simon J
Publicado em 2013

The Repertoire of Fos and Jun Proteins Expressed during the G(1) Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase Activation

Por Cook, Simon J., Aziz, Natasha, McMahon, Martin
Publicado em 1999

Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.

Por Squires, Matthew S, Nixon, Paula M, Cook, Simon J
Publicado em 2002

c-Cbl is not required for ERK1/2-dependent degradation of Bim(EL)

Por Wiggins, Ceri M., Band, Hamid, Cook, Simon J.
Publicado em 2007

ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death

Por Darling, Nicola J., Balmanno, Kathryn, Cook, Simon J.
Publicado no PLoS One (2017)

ΔRaf-1:ER* Bypasses the Cyclic AMP Block of Extracellular Signal-Regulated Kinase 1 and 2 Activation but Not CDK2 Activation or Cell Cycle Reentry

Por Balmanno, Kathryn, Millar, Tracy, McMahon, Martin, Cook, Simon J.
Publicado em 2003

MEK Inhibitor U0126 Reverses Protection of Axons from Wallerian Degeneration Independently of MEK–ERK Signaling

Por Evans, Catherine, Cook, Simon J., Coleman, Michael P., Gilley, Jonathan
Publicado em 2013

Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1.

Por Chalmers, Claire J, Balmanno, Kathryn, Hadfield, Kathryn, Ley, Rebecca, Cook, Simon J
Publicado em 2003

Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf–MEK–ERK 1/2 pathway

Por Krueger, Felix, Madeja, Zofia, Hemberger, Myriam, McMahon, Martin, Cook, Simon J., Gaunt, Stephen J.
Publicado no Cell Signal (2009)

GM-CSF CAUSES A PARADOXICAL INCREASE IN THE BH3-ONLY PRO-APOPTOTIC PROTEIN BIM IN HUMAN NEUTROPHILS

Por Cowburn, Andrew S, Summers, Charlotte, Dunmore, Benjamin J, Farahi, Neda, Print, Cristin G, Cook, Simon J, Chilvers, Edwin R
Publicado no Am J Respir Cell Mol Biol (2010)

Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

Por Cambuli, Francesco, Murray, Alexander, Dean, Wendy, Dudzinska, Dominika, Krueger, Felix, Andrews, Simon, Senner, Claire E., Cook, Simon J., Hemberger, Myriam
Publicado no Nat Commun (2014)

Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release

Por Dautova, Yana, Kapustin, Alexander N., Pappert, Kevin, Epple, Matthias, Okkenhaug, Hanneke, Cook, Simon J., Shanahan, Catherine M., Bootman, Martin D., Proudfoot, Diane
Publicado no J Mol Cell Cardiol (2018)

ERK1/2-dependent phosphorylation of Bim(EL) promotes its rapid dissociation from Mcl-1 and Bcl-x(L)

Por Ewings, Katherine E, Hadfield-Moorhouse, Kathryn, Wiggins, Ceri M, Wickenden, Julie A, Balmanno, Kathryn, Gilley, Rebecca, Degenhardt, Kurt, White, Eileen, Cook, Simon J
Publicado em 2007

(V600E)Braf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16(INK4a)

Por Carragher, Linda A S, Snell, Kimberley R, Giblett, Susan M, Aldridge, Victoria S S, Patel, Bipin, Cook, Simon J, Winton, Doug J, Marais, Richard, Pritchard, Catrin A
Publicado em 2010

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

Por Najas, Sònia, Arranz, Juan, Lochhead, Pamela A., Ashford, Anne L., Oxley, David, Delabar, Jean M., Cook, Simon J., Barallobre, María José, Arbonés, Maria L.
Publicado no EBioMedicine (2015)

Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation

Por Lochhead, Pamela A., Clark, Jonathan, Wang, Lan-Zhen, Gilmour, Lesley, Squires, Matthew, Gilley, Rebecca, Foxton, Caroline, Newell, David R., Wedge, Stephen R., Cook, Simon J.
Publicado no Cell Cycle (2016)

Maternal DNA Methylation Regulates Early Trophoblast Development

Por Branco, Miguel R., King, Michelle, Perez-Garcia, Vicente, Bogutz, Aaron B., Caley, Matthew, Fineberg, Elena, Lefebvre, Louis, Cook, Simon J., Dean, Wendy, Hemberger, Myriam, Reik, Wolf
Publicado no Dev Cell (2016)

FGF signalling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency

Por Ficz, Gabriella, Hore, Timothy A, Santos, Fatima, Lee, Heather J, Dean, Wendy, Arand, Julia, Krueger, Felix, Oxley, David, Paul, Yu-Lee, Walter, Jörn, Cook, Simon J, Andrews, Simon, Branco, Miguel R, Reik, Wolf
Publicado em 2013

FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency

Por Ficz, Gabriella, Hore, Timothy A., Santos, Fátima, Lee, Heather J., Dean, Wendy, Arand, Julia, Krueger, Felix, Oxley, David, Paul, Yu-Lee, Walter, Jörn, Cook, Simon J., Andrews, Simon, Branco, Miguel R., Reik, Wolf
Publicado em 2013