ERK1/2-dependent phosphorylation of Bim(EL) promotes its rapid dissociation from Mcl-1 and Bcl-x(L)

The proapoptotic protein Bim is expressed de novo following withdrawal of serum survival factors. Here, we show that Bim−/− fibroblasts and epithelial cells exhibit reduced cell death following serum withdrawal in comparison with their wild-type counterparts. In viable cells, Bax associates with Bcl...

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Detalhes bibliográficos
Main Authors: Ewings, Katherine E, Hadfield-Moorhouse, Kathryn, Wiggins, Ceri M, Wickenden, Julie A, Balmanno, Kathryn, Gilley, Rebecca, Degenhardt, Kurt, White, Eileen, Cook, Simon J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1894764/
https://ncbi.nlm.nih.gov/pubmed/17525735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601723
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