Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-x(L)/Bcl-2 in Mcl-1–expressing myeloma cells

Dependence on Bcl-2 proteins is a common feature of cancer cells and provides a therapeutic opportunity. ABT-737 is an antagonist of antiapoptotic Bcl-2 proteins and therefore is a good predictor of Bcl-x(L)/Bcl-2 dependence. Surprisingly, analysis of Mcl-1–dependent multiple myeloma cell lines reve...

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Detalhes bibliográficos
Main Authors: Morales, Alejo A., Kurtoglu, Metin, Matulis, Shannon M., Liu, Jiangxia, Siefker, David, Gutman, Delia M., Kaufman, Jonathan L., Lee, Kelvin P., Lonial, Sagar, Boise, Lawrence H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152498/
https://ncbi.nlm.nih.gov/pubmed/21659544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-327197
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