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Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1.

To investigate the role of thrombin in regulating apoptosis, we have used CCl39 cells, a fibroblast cell line in which thrombin-induced cell proliferation has been extensively studied. Withdrawal of serum from CCl39 cells resulted in a rapid apoptotic response that was completely prevented by the in...

詳細記述

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書誌詳細
主要な著者: Chalmers, Claire J, Balmanno, Kathryn, Hadfield, Kathryn, Ley, Rebecca, Cook, Simon J
フォーマット: Artigo
言語:Inglês
出版事項: 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223666/
https://ncbi.nlm.nih.gov/pubmed/12844349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030346
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