Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM

The RAF-mitogen-activated protein kinase kinase 1/2-extracellular signal-regulated kinase 1/2 (RAF-MEK1/2-ERK1/2) pathway is activated in many human tumours and can protect cells against growth factor deprivation; however, most such studies have relied upon overexpression of RAF or MEK constructs th...

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Detalhes bibliográficos
Main Authors: Wickenden, JA, Jin, H, Johnson, M, Gillings, AS, Newson, C, Austin, M, Chell, SD, Balmanno, K, Pritchard, CA, Cook, SJ
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643813/
https://ncbi.nlm.nih.gov/pubmed/18806830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.335
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