Sustained ERK inhibition maximizes responses of Braf(V600E) thyroid cancers to radioiodine

Radioiodide (RAI) therapy of thyroid cancer exploits the relatively selective ability of thyroid cells to transport and accumulate iodide. Iodide uptake requires expression of critical genes that are involved in various steps of thyroid hormone biosynthesis. ERK signaling, which is markedly increase...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Nagarajah, James, Le, Mina, Knauf, Jeffrey A., Ferrandino, Giuseppe, Montero-Conde, Cristina, Pillarsetty, Nagavarakishore, Bolaender, Alexander, Irwin, Christopher, Krishnamoorthy, Gnana Prakasam, Saqcena, Mahesh, Larson, Steven M., Ho, Alan L., Seshan, Venkatraman, Ishii, Nobuya, Carrasco, Nancy, Rosen, Neal, Weber, Wolfgang A., Fagin, James A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2016
Onderwerpen:
Brief Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096947/
https://ncbi.nlm.nih.gov/pubmed/27669459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89067
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