Sustained ERK inhibition maximizes responses of Braf(V600E) thyroid cancers to radioiodine

Radioiodide (RAI) therapy of thyroid cancer exploits the relatively selective ability of thyroid cells to transport and accumulate iodide. Iodide uptake requires expression of critical genes that are involved in various steps of thyroid hormone biosynthesis. ERK signaling, which is markedly increase...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Nagarajah, James, Le, Mina, Knauf, Jeffrey A., Ferrandino, Giuseppe, Montero-Conde, Cristina, Pillarsetty, Nagavarakishore, Bolaender, Alexander, Irwin, Christopher, Krishnamoorthy, Gnana Prakasam, Saqcena, Mahesh, Larson, Steven M., Ho, Alan L., Seshan, Venkatraman, Ishii, Nobuya, Carrasco, Nancy, Rosen, Neal, Weber, Wolfgang A., Fagin, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096947/
https://ncbi.nlm.nih.gov/pubmed/27669459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89067
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