Co-inhibition of SMAD and MAPK signaling enhances (124)I uptake in BRAF-mutant thyroid cancers

Constitutive MAPK activation silences genes required for iodide uptake and thyroid hormone biosynthesis in thyroid follicular cells. Accordingly, most BRAF(V600E) papillary thyroid cancers (PTC) are refractory to radioiodide (RAI) therapy. MAPK pathway inhibitors rescue thyroid-differentiated proper...

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Bibliografiske detaljer
Udgivet i:Endocr Relat Cancer
Main Authors: Luckett, Kathleen A, Cracchiolo, Jennifer R, Krishnamoorthy, Gnana P, Leandro-Garcia, Luis Javier, Nagarajah, James, Saqcena, Mahesh, Lester, Rona, Im, Soo Y, Zhao, Zhen, Lowe, Scott W, de Stanchina, Elisa, Sherman, Eric J, Ho, Alan L, Leach, Steven D, Knauf, Jeffrey A, Fagin, James A
Format: Artigo
Sprog:Inglês
Udgivet: Bioscientifica Ltd 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183640/
https://ncbi.nlm.nih.gov/pubmed/33890869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-21-0017
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