EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC

Translation initiation is orchestrated by the cap binding and 43S pre-initiation complexes (PIC). Eukaryotic initiation factor 1A (EIF1A) is essential for recruitment of the ternary complex and for assembling the 43S PIC. Recurrent EIF1AX mutations in papillary thyroid cancers are mutually exclusive...

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Bibliografske podrobnosti
izdano v:Cancer Discov
Main Authors: Krishnamoorthy, Gnana P., Davidson, Natalie R., Leach, Steven D., Zhao, Zhen, Lowe, Scott W., Lee, Gina, Landa, Iňigo, Nagarajah, James, Saqcena, Mahesh, Singh, Kamini, Wendel, Hans-Guido, Dogan, Snjezana, Tamarapu, Prasanna P., Blenis, John, Ghossein, Ronald A., Knauf, Jeffrey A., Rätsch, Gunnar, Fagin, James A.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373451/
https://ncbi.nlm.nih.gov/pubmed/30305285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0606
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