EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC

Translation initiation is orchestrated by the cap binding and 43S pre-initiation complexes (PIC). Eukaryotic initiation factor 1A (EIF1A) is essential for recruitment of the ternary complex and for assembling the 43S PIC. Recurrent EIF1AX mutations in papillary thyroid cancers are mutually exclusive...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cancer Discov
मुख्य लेखकों: Krishnamoorthy, Gnana P., Davidson, Natalie R., Leach, Steven D., Zhao, Zhen, Lowe, Scott W., Lee, Gina, Landa, Iňigo, Nagarajah, James, Saqcena, Mahesh, Singh, Kamini, Wendel, Hans-Guido, Dogan, Snjezana, Tamarapu, Prasanna P., Blenis, John, Ghossein, Ronald A., Knauf, Jeffrey A., Rätsch, Gunnar, Fagin, James A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2018
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373451/
https://ncbi.nlm.nih.gov/pubmed/30305285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0606
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