Co-inhibition of SMAD and MAPK signaling enhances (124)I uptake in BRAF-mutant thyroid cancers

Constitutive MAPK activation silences genes required for iodide uptake and thyroid hormone biosynthesis in thyroid follicular cells. Accordingly, most BRAF(V600E) papillary thyroid cancers (PTC) are refractory to radioiodide (RAI) therapy. MAPK pathway inhibitors rescue thyroid-differentiated proper...

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Detaylı Bibliyografya
Yayımlandı:Endocr Relat Cancer
Asıl Yazarlar: Luckett, Kathleen A, Cracchiolo, Jennifer R, Krishnamoorthy, Gnana P, Leandro-Garcia, Luis Javier, Nagarajah, James, Saqcena, Mahesh, Lester, Rona, Im, Soo Y, Zhao, Zhen, Lowe, Scott W, de Stanchina, Elisa, Sherman, Eric J, Ho, Alan L, Leach, Steven D, Knauf, Jeffrey A, Fagin, James A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Bioscientifica Ltd 2021
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183640/
https://ncbi.nlm.nih.gov/pubmed/33890869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-21-0017
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