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c-Cbl is not required for ERK1/2-dependent degradation of Bim(EL)
Bim(EL) the most abundant Bim splice variant, is subject to ERK1/2-catalysed phosphorylation, which targets it for ubiquitination and proteasome-dependent destruction. In contrast, inactivation of ERK1/2, following withdrawal of survival factors, promotes stabilization of Bim(EL). It has been propos...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2707770/ https://ncbi.nlm.nih.gov/pubmed/17884340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2007.08.008 |
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