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c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130

Interleukin 6 (IL-6), a pleiotropic cytokine, functions in cells through its interaction with its receptor complex, which consists of two ligand-binding α subunits and two signal-transducing subunits known as gp130. There is a wealth of studies on signals mediated by gp130, but its downregulation is...

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Detalhes bibliográficos
Main Authors: Tanaka, Yoshinori, Tanaka, Nobuyuki, Saeki, Yasushi, Tanaka, Keiji, Murakami, Masaaki, Hirano, Toshio, Ishii, Naoto, Sugamura, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493370/
https://ncbi.nlm.nih.gov/pubmed/18519587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01784-07
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