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Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors

Addition of ubiquitin or ubiquitin chains to target proteins leads to their mono- or polyubiquitination, respectively. Whereas polyubiquitination targets proteins for degradation, monoubiquitination is thought to regulate receptor internalization and endosomal sorting. Cbl proteins are major ubiquit...

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Bibliografiske detaljer
Main Authors: Haglund, Kaisa, Shimokawa, Noriaki, Szymkiewicz, Iwona, Dikic, Ivan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC129420/
https://ncbi.nlm.nih.gov/pubmed/12218189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192462299
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