Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors

Addition of ubiquitin or ubiquitin chains to target proteins leads to their mono- or polyubiquitination, respectively. Whereas polyubiquitination targets proteins for degradation, monoubiquitination is thought to regulate receptor internalization and endosomal sorting. Cbl proteins are major ubiquit...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Haglund, Kaisa, Shimokawa, Noriaki, Szymkiewicz, Iwona, Dikic, Ivan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129420/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12218189/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.192462299
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