Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7–dependent homeostatic proliferation of CD4(+) T cells

Mice homozygous for the F759 mutation in the gp130 interleukin (IL)-6 receptor subunit have enhanced gp130-mediated signal transducer and activator of transcription (STAT)3 activation and spontaneously developed a lymphocyte-mediated rheumatoid arthritis-like joint disease. Here, we show that the de...

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Hlavní autoři: Sawa, Shin-ichiro, Kamimura, Daisuke, Jin, Gui-Hua, Morikawa, Hideyuki, Kamon, Hokuto, Nishihara, Mika, Ishihara, Katsuhiko, Murakami, Masaaki, Hirano, Toshio
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118324/
https://ncbi.nlm.nih.gov/pubmed/16717113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052187
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