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A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis
We generated a mouse line in which the src homology 2 domain–bearing protein tyrosine phosphatase (SHP)-2 binding site of gp130, tyrosine 759, was mutated to phenylalanine (gp130 (F759/F759)). The gp130 (F759/F759) mice developed rheumatoid arthritis (RA)-like joint disease. The disease was accompan...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The Rockefeller University Press
2002
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2194024/ https://ncbi.nlm.nih.gov/pubmed/12370259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020619 |
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