A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis

We generated a mouse line in which the src homology 2 domain–bearing protein tyrosine phosphatase (SHP)-2 binding site of gp130, tyrosine 759, was mutated to phenylalanine (gp130 (F759/F759)). The gp130 (F759/F759) mice developed rheumatoid arthritis (RA)-like joint disease. The disease was accompan...

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Detalhes bibliográficos
Main Authors: Atsumi, Toru, Ishihara, Katsuhiko, Kamimura, Daisuke, Ikushima, Hideto, Ohtani, Takuya, Hirota, Seiichi, Kobayashi, Hideyuki, Park, Sung-Joo, Saeki, Yukihiko, Kitamura, Yukihiko, Hirano, Toshio
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194024/
https://ncbi.nlm.nih.gov/pubmed/12370259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020619
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