Homeostatically proliferating CD4(+) T cells are involved in the pathogenesis of an Omenn syndrome murine model

Patients with Omenn syndrome (OS) have hypomorphic RAG mutations and develop varying manifestations of severe combined immunodeficiency. It is not known which symptoms are caused directly by the RAG mutations and which depend on other polymorphic genes. Our current understanding of OS is limited by...

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Main Authors: Khiong, Khie, Murakami, Masaaki, Kitabayashi, Chika, Ueda, Naoko, Sawa, Shin-ichiro, Sakamoto, Akemi, Kotzin, Brian L., Rozzo, Stephen J., Ishihara, Katsuhiko, Verella-Garcia, Marileila, Kappler, John, Marrack, Philippa, Hirano, Toshio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857265/
https://ncbi.nlm.nih.gov/pubmed/17476359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30513
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