Homeostatically proliferating CD4(+) T cells are involved in the pathogenesis of an Omenn syndrome murine model

Patients with Omenn syndrome (OS) have hypomorphic RAG mutations and develop varying manifestations of severe combined immunodeficiency. It is not known which symptoms are caused directly by the RAG mutations and which depend on other polymorphic genes. Our current understanding of OS is limited by...

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Detalhes bibliográficos
Main Authors: Khiong, Khie, Murakami, Masaaki, Kitabayashi, Chika, Ueda, Naoko, Sawa, Shin-ichiro, Sakamoto, Akemi, Kotzin, Brian L., Rozzo, Stephen J., Ishihara, Katsuhiko, Verella-Garcia, Marileila, Kappler, John, Marrack, Philippa, Hirano, Toshio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857265/
https://ncbi.nlm.nih.gov/pubmed/17476359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30513
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