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Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases?
The strong association between particular MHCII alleles and type 1 diabetes is not fully understood. Two ideas that have been considered for many years are that autoimmunity is driven by (1) low-affinity CD4(+) T cells that escape thymic negative selection and respond to certain autoantigen peptides...
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| Format: | Artigo |
| Jezik: | Inglês |
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Cold Spring Harbor Laboratory Press
2012
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3426820/ https://ncbi.nlm.nih.gov/pubmed/22951444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a007765 |
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