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TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice

Although autoantibodies are the hallmarks of most autoimmune diseases, the mechanisms by which autoreactive B cells are generated and accumulate are still poorly understood. Overexpression of Toll-like receptor 7 (TLR7) that recognizes single-stranded RNAs has been implicated in systemic lupus eryth...

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Autors principals: Rubtsov, Anatoly V., Rubtsova, Kira, Kappler, John W., Marrack, Philippa
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935605/
https://ncbi.nlm.nih.gov/pubmed/22945807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12026-012-8365-8
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