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Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interacti...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1223168/ https://ncbi.nlm.nih.gov/pubmed/12475393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021539 |
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